Simple find/replace compared to Advanced search/replace.
Simple find/replace is found in the Edit menu. Its shortcut is control+H. Advanced find/replace is in the Plugins menu, in the TextFX Quick menu. Its shortcut is control+R.
I finally researched an issue I was having with finding tab, new line, carriage return characters at the beginning of the line. I have an automated SQL procedure to create product data feeds in a tab delimited format. One of the symptoms of a soft SQL failure is that the line will wrap. This situation can be detected by looking for a first character that is either a tab, new line, or carriage return using the regex expression ^[\t\n\r]. . The simple find/replace does not find the problem lines while the Advanced version works as expected.